MSM Overview
Methylsulfonylmethane is a dietary supplement form of
sulfur that is found in our living tissues. MSM supports
healthy connective tissues like tendons, ligaments, and
muscle. Thus, it is important in conditions such as
arthritis, muscle pains, bursitis, etc. MSM should be
considered an integral part of any healthcare practice
because of its physiological action, indirect
importance, and current/future uses.
To understand MSM, some background information is
necessary. MSM is a “naturally-occurring nutrient found
in normal human diets”. It gets into the diet through
the sulfur cycle. Ocean plankton release sulfur
compounds which rise into the ozone where ultra-violet
light makes MSM and DMSO. DMSO, dimethyl sulfoxide, is a
precursor to MSM. MSM and DMSO return to the surface of
the earth in rain. Plants concentrate MSM and return it
to the earth and the sea. Evaporation into the air
results in their return to the earth.
MSM has a unique action on body tissues. It decreases
the pressure inside the cell. In removing fluids and
toxins, sulfur affects the cell membrane. MSM is an
organic form of sulfur, whereas sulfites in foodstuffs
are inorganic. Sue Williams states “sulfur is present in
all cells” and is in the form of “organic compounds
throughout the body. However, sulfur can be found in the
body in sulfate forms. It forms sulfate compounds with
sodium, potassium, magnesium, and selenium. MSM has a
significance because sulfur compounds are found
everywhere throughout the body and in nature.
Sulfur has an indirect importance because sulfur
compounds play a role in many body organs and systems.
Sulfur is in the hair, skin, and nails. Many amino
acids, the building blocks of protein, have sulfur as a
component. Taurine is a sulfur-containing amino acid
formed from methionine. Taurine stabilizes cell
membranes. Methionine contains sulfur, detoxifies cells,
and is involved in pain relief. Carnitine comes from
methionine and transports long-chain fatty acids
preventing accumulations of lipoproteins. Many B-complex
vitamins interact with or contain sulfur. Sulfur is
needed for insulin production.
One current use of MSM is for joint problems, as sulfur
is found in and near osseous structures. Sulfur supports
healthy muscles, tendons, and ligaments. Arthritic
conditions have responded to oral MSM. Some researchers
note results from MSM when used for post-exercise muscle
pain. MSM normalizes pressure inside cells and removes
toxins. Oregon Health Sciences University has conducted
arthritis studies with mice. The mice which received MSM
had “no degeneration of articular cartilage”. The other
non-MSM mice had cartilaginous degeneration. The
university has used MSM on over 12,000 patents.
Researchers make no claim about MSM as a supplement, but
osteoarthritis, rheumatoid arthritis, muscle soreness
and muscle pain respond to oral MSM.
One researcher claims MSM is about as safe as water. One
should drink extra water with MSM use. There are other
dietary factors to consider.
Extreme Close-Up of Pure
MSM in it's crystalline state |
Avoiding
nightshade plants has helped arthritis patients
(tomatoes/potatoes / green pepper/eggplant). Biotin and
vitamin C help the body assimilate MSM. Biotin and
vitamin C are found in fresh fruits. Eating fresh fruits
while taking MSM could be helpful.
In addition to arthritis, it may have other future uses.
Dr. Stanley Jacob believes,’most people are deficient’
in sulfur. Insulin synthesis depends upon sulfur. Many
vitamins require or contain sulfur. Some researchers
claim it has many future uses such as in allergies.
A good MSM product is both safe and effective. The MSM
source for MSM supplements is often lignin from pine
trees. Lignin is a molecule in plants that is part of a
plant’s cell wall. Lignin oxidation in oak wine barrels
results in the vanilla flavors of wines. The pine tree
lignin is an ideal source for a good MSM product.
For those who do not want to take MSM as a supplement,
food sources of sulfur are as follows: sunflower seeds,
garlic, lentils, soybeans, and yogurt. Persons with
kidney problems or recurrent kidney stones may not want
to take MSM. Certain renal tubular defects can make a
person susceptible to recurrent kidney stones. Other
kidney defects include errors of metabolism in which
processing of sulfur amino acids is altered. Such
persons may wish to avoid MSM.
One thousand to three thousand milligrams per day is a
typical dosage range, but some people take well above
that amount. This author takes MSM alone.
From the cell walls of pine trees to the cells of the
human body, a good MSM supplement can contribute to good
health.
Conditions
That Have Responded to MSM Supplements...
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Acne
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Allergies
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Arthritis
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Asthma
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Candida Yeast Infections
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Carpal Tunnel Syndrome
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Chronic Fatigue
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Constipation
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Diabetes
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Digestive Disorders
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Fragile Hair & Nails
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Migraine Headaches
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Muscle Pain & Cramps
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Parasites
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Skin
Damage & Aging
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Toxic
Build-up
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Ulcers
A body
made up of healthy, flexible cells will not only feel
better, it will look better too. The body is
continuously at work replacing old, worn out cells with
new ones. The process goes on 24 hours a day, 7 days a
week, without stop. When all the raw materials needed
for cell-building are available, it is a very efficient
process. When there are deficiencies, the new cells may
be weak, rigid or deformed.
One of the most important raw materials for building
healthy new cells is a form of organic sulfur known as
methyl sulfonyl methane (MSM). This element is so
essential to life that it is found in every cell of
every plant and every animal. Sulfur makes up 0.25% of
human body weight. However, neither plants nor animals
can use elemental sulfur directly. Sulfur is not easily
available to living organisms in its inorganic form.
MSM is not a medicine, a drug, or a food additive. It is
a food. MSM is an organic form of sulfur that can be
easily absorbed and utilized by the body. Although DMSO
and MSM are chemically similar, each is unique. MSM is a
pure, stable, white crystalline powder without the
unpleasant smell or taste of DMSO. Also, MSM does not
give you a strong body odor like DMSO.
Since sulfur is a component of all cells, it is
essential that the body has a plentiful supply of this
mineral in its usable form. There is a positive
synergistic effect on building healthier cells when MSM
is taken in combination with vitamin C.The new cells are
more pliable and permeable, allowing fluids to pass
through the tissue more easily. Internally this means a
more efficient elimination of toxins, a reduction in
inflammation and pain – so you feel better. On the
outside it shows up as a softer, smoother complexion,
stronger hair and nails – so you look better.
MSM for Relief
of Pain and Inflammation
Approximately half of the total body sulfur is
concentrated in the muscles, skin, and bones. One of the
most significant uses of MSM as a supplement is its
demonstrated ability to relieve pain and inflammation.
When rigid fibrous tissue cells swell and become
inflamed, pressure and pain result. Since MSM can
restore flexibility and permeability to cell walls,
fluids can pass through the tissues more easily. This
helps equalize pressure and reduce or eliminate the
cause of pain. Harmful substances such as lactic acid
and toxins are allowed to flow out, while nutrients are
permitted to flow in. This prevents the pressure buildup
in cells that cause inflammation.
MSM has shown a remarkable ability to reduce or
eliminate muscle soreness and cramps both in geriatric
patients and in athletes. It’s even given to racehorses
before a race to prevent muscle soreness, and afterward
to reduce the risk of cramping. People with arthritis
report substantial and long-lasting relief with MSM
supplements. Taken along with glucosamine, a key
substance in the process of rebuilding cartilage, MSM
can relieve pain and help repair worn or damaged
cartilage in joints, ligaments, and tendons with
healthy, flexible new cells.
How Does MSM
Work?
MSM makes cell walls permeable, allowing water and
nutrients to freely flow into cells and allowing wastes
and toxins to properly flow out. The body uses MSM along
with Vitamin C to create new, healthy cells, and MSM
provides the flexible bond between the cells. Without
proper levels of MSM, our bodies are unable to build
good healthy cells, and this leads to problems such as
lost flexibility, scar tissue, wrinkles, varicose veins,
hardened arteries, damaged lung tissues, dry cracking
skin, digestive disorders, joint problems, and inability
to defend against allergic reactions to food, animals,
and plants.
MSM is an anti-oxidant that helps to clean the
bloodstream and flush toxins trapped in our cells. It is
also a foreign protein and free radical scavenger. In
order to maintain good health, we need to supplement our
diets with MSM, to enable the body to heal itself. The
body uses what it needs, and after 12 hours will flush
out any excess amounts.
The Beauty
Mineral for Hair, Skin, and Nails
Sulfur has been called nature’s “beauty mineral” because
it is needed to keep the hair glossy and smooth and
keeps the complexion clear and youthful. It is needed
for synthesis of collagen and is prevalent in keratin, a
tough protein substance necessary for health and
maintenance of the skin, nails, and hair.
MSM is responsible for the flexible disulfide bonds
between cells, including those that make up the skin. It
blocks undesirable chemical and physical cross-linking
or bonding of collagen which is associated with tough,
aging skin. Con consequently MSM enhances tissue
pliability and encourages repair f damaged skin. If
there is insufficient sulfur in the body when new cells
are being manufactured, the new cells will be rigid.
This rigidity can contribute to cracking, wrinkling, and
unsightly scar tissue. When sufficient sulfur is present
for new cells, the skin is softer, smoother and more
flexible. MSM provides that sulfur.
Acne, including the severe acne rosacea, responds
favorably to MSM supplements. Adequate sulfur and
vitamin C are also needed for healing. When the body is
deficient in these nutrients, the new tissue will be
elevated leaving an unattractive, raised scar. Because
MSM makes the skin more permeable and pliant, it can
also help prevent blistering and promote faster healing
from sunburn or wind damage.
With MSM supplements, nails show not only an increase in
growth rate but also increased toughness and resistance
to chipping and cracking. This effect has been seen both
in human nails and horses hoofs.
Allergens,
Toxins, and Parasites
Flexible, permeable cells are also important in that
they allow toxins, allergens, and foreign substances to
be flushed out of the body more easily. When skin cells
are soft and permeable, many toxins can be eliminated
through the sweat glands, which takes some of the load
off the liver and kidneys. While MSM is not a cure for
allergies, supplementation may reduce symptoms by
allowing allergens to be removed from the body more
quickly. Even reactions to insect bites, poison ivy, and
poison oak are less severe when the diet is supplemented
with MSM. Vitamin C is also synergistic in this
application in that it can lower histamine levels.
MSM has also shown amazing anti-parasitic action against
Giardia, Trichomonas, roundworms, nematodes, Enterobius
and other intestinal worms. When parasites attach
themselves to the intestinal lining, they can live,
reproduce and rob the body of nutrients indefinitely.
MSM blocks parasites by competing for receptor sites on
the mucous membrane. When parasites cannot attach
themselves, they are simply flushed out of the system.
The same is true with food allergens. MSM coats mucosal
surfaces and occupies the binding sites that could
otherwise be used by challenging food allergens. It can
also bind with offending agents to produce harmless
substances which are then excreted from the body. This
facilitates normal digestion and assimilation and allows
the body to get maximum nutritional value from foods
that would otherwise cause a reaction. Individuals who
experience an allergic response to certain foods have
reported improved or complete tolerance to those foods
when they take MSM supplements. Healthy flexible colon
tissues along with improved digestion can also relieve
constipation.
Diabetes
Sulfur is also a component of insulin, the hormone that
regulates carbohydrate metabolism and insufficient
sulfur may result in decreased insulin production. It is
also possible that a lack of bio-available sulfur would
make the cells so rigid and impermeable that they become
unable to absorb sugar from the blood efficiently,
leaving blood sugar levels elevated. Studies indicate
that regular MSM supplements which cause the cell to
become permeable could help balance blood sugar and
allow the overworked pancreas to return to normal.
Why
Supplement?
Since sulfur is present in every cell of every living
thing, it might seem that we would get plenty of this
essential mineral from dietary sources and should not
need supplements, but that may not be the case. Meat,
poultry, fish, eggs, and dairy products are the main
sources of dietary sulfur, but we have been advised to
restrict or remove many of those foods from our diets.
Vegetarians, especially those who do not eat eggs, are
at particular risk for sulfur deficiency. Plants cells
contain sulfur but not in abundant quantities and much
of the MSM present in unprocessed foods is lost in
washing, cooking or steaming. And, of course, MSM levels
decline noticeably with age – doesn’t everything? So,
the older you get, the more important it becomes to
maintain adequate sulfur levels in the body.
Usage and
Toxicity
Due to its positive effects, particularly in maintaining
healthy cell formation, 2,000 to 6,000 mg. of
supplemental MSM daily is recommended. Of course, the
optimum daily dosage of MSM depends largely on body
size, age and the nature and severity of any deficiency
symptoms you may be experiencing. Since vitamin C
provides a positive synergistic it should be taken along
with MSM.
MSM ranks in the “extremely low” toxicity category with
a toxicity profile similar to that of water. When oral
supplements are taken, the body will distribute MSM
where it is needed. After about 12 hours, any excess
amounts will be flushed out of the body. MSM, a member
of the sulfur family, should never be confused with
sulfa drugs to which some people are allergic.
Further Reading
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Sulfur -
the 4th most abundant mineral in the human body
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Georges
Hareau and Philip Kocienski, "Dimethyl Sulfone" in
Encyclopedia of Reagents for Organic Synthesis 2001
John Wiley & Sons. DOI: 10.1002/047084289X.rd371
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Barrager
E, Veltmann JR, Schauss AG, Schiller RN. A
multi-centered, open label trial on the safety and
efficacy of methylsulfonylmethane in the treatment
of seasonal allergic rhinitis. J Altern
Complement Med 2002;8:167–74. PMID 12006124
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Blum JM,
Blum RI. The effect of methylsulfonylmethane (MSM)
in the control of snoring. Integrative Medicine
2004;3(6)24-30.
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Childs
SJ. Dimethyl sulfone (DMSO2) in the treatment of
interstitial cystitis. Urol Clin North Am
1994;21:85–8. PMID 8284850
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Engelke
UF, Tangerman A, Willemsen MA, Moskau D, Loss S,
Mudd SH, Wevers RA. Dimethyl sulfone in human
cerebrospinal fluid and blood plasma confirmed by
one-dimensional (1)H and two-dimensional (1)H-(13)C
NMR. NMR Biomed 2005 Aug;18(5):331-6. PMID
15996001
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Horv?th
K, Noker PE, Somfai-Relle S, et al.
Toxicity of methylsulfonylmethane in rats. Food
Chem Toxicol 2002;40:1459–62. PMID 12387309
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Jacob SW,
Appleton J. MSM-The Definitive Guide
(Topanga, Freedom Press, 2003) ISBN 1-893910-21-0
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Kim LS,
Axelrod LJ, Howard P, Buratovich N, Waters RF.
Efficacy of methylsulfonylmethane (MSM) in
osteoarthritis pain of the knee: a pilot clinical
trial. Osteoarthritis Cartilage
2006;14(3):286–94. PMID 16309928
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King CJ.
Separation Processes, 2nd ed. New York,
McGraw-Hill, 1980. ISBN 0-07-034612-7
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Kocsis
JJ, Harkaway S, Snyder R. Biological effects of the
metabolites of dimethyl sulfoxide.
Ann N Y Acad Sci 1975;243:104–9. PMID 1055534
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Lin A,
Nguy CH, Shic F, Ross BD. Accumulation of
methylsulfonylmethane in the human brain:
identification by multinuclear magnetic resonance
spectroscopy. Toxicol Lett 2001;123:169–77.
PMID 11641045
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Morton
JI, Siegel BV. Effects of oral dimethyl sulfoxide
and dimethyl sulfone on murine autoimmune
lymphoproliferative disease. Proc Soc Exp Biol
Med 1986;183:227–30. PMID 3489943
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Murav'ev
IuV, Venikova MS, Pleskovskaia GN,
et al. [Effect of dimethyl sulfoxide and
dimethyl sulfone on a destructive process in the
joints of mice with spontaneous arthritis]. Patol
Fiziol Eksp Ter 1991;(2):37–9 [in Russian]. PMID
1881708
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Pearson
TW, Dawson HJ, Lackey HB. Natural occurring levels
of dimethyl sulfoxide in selected fruits,
vegetables, grains and beverages. J Agric Food
Chem 1981;29:1019–21. PMID 7309994
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Pfiffner
JJ, North HB. Dimethyl sulfone: A constituent of the
adrenal gland. J Biol Chem
1940;134:781–2. PDF online.
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Rose SE,
Chalk JB, Galloway GJ, Doddrell DM. Detection of
dimethyl sulfone in the human brain by
in vivo proton magnetic resonance
spectroscopy. Magn Reson Imaging
2000;18:95–8. PMID 10642107
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Usha PR,
Naidu MUR. Randomised, double-blind, parallel,
placebo-controlled study of oral glucosamine,
methylsulfonylmethane and their combination in
osteoarthritis. Clin Drug Invest
2004;24(6):353–63.
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Williams
KIH, Burstein SH, Layne DS. Dimethyl sulfone:
isolation from cows’ milk. Proc Soc Exp Biol Med
1966;122:865–6. PMID 5918965
-
Williams
KIH, Burstein SH, Layne. Metabolism of dimethyl
sulfide, dimethyl sulfoxide, and dimethyl sulfone in
the rabbit. Arch Biochem Biophys
1966;117:84–7. PMID 5971744
Our MSM has been laboratory tested
and is certified to be 99.9% pure.
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